Key result
The adrenoceptors of rat atria are affected by temperature, with a transition from beta- to alpha-adrenoceptor properties at lower temperatures that is dependent on sympathetic innervation.
Population
Rat heart preparations
Comparison
Exposure to various alpha- and beta-adrenoceptor… vs Responses at different temperatures and between…
Design
Preclinical
Authors
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Should not yet alter clinical practice; leaves open translation of temperature-dependent adrenoceptor shifts to humans.
Temperature alters the pharmacological properties of rat atrial adrenoceptors, shifting from beta- to alpha-characteristics at lower temperatures, a process dependent on intact sympathetic innervation.
Kunos et al. (1977) studied this question. Temperature changes and sympathetic innervation was evaluated on Pharmacological characteristics of adrenoceptors. The adrenoceptors of rat atria are affected by temperature, with a transition from beta- to alpha-adrenoceptor properties at lower temperatures that is dependent on sympathetic innervation.
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