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January 1, 2012Sunhwan'giOpen Access

Recurrent Deep Vein Thrombosis due to Thrombophilia

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Key result

A 40-year-old man with recurrent deep vein thrombosis was diagnosed with hereditary thrombophilia due to combined protein C and protein S deficiency, requiring lifelong warfarin prophylaxis.

Population

40-year-old non-smoker, non-diabetic, normotensive male with recurrent deep vein thrombosis (n=1)

Design

Case_report

Follow-up

two-years

Authors

ARAfzalur RahmanUnited HospitalAIAKM Monwarul IslamBangladesh Institute of Research and Rehabilitation for Diabetes Endocrine and Metabolic DisordersSHSam Husnayen

Discussion

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Implication

Recurrent DVT may prompt thrombophilia evaluation; single case leaves open optimal anticoagulation duration.

Study Design

Type

Case Report (n=1)

Structured PICO

P
Population
A 40-year-old man with recurrent deep vein thrombosis who was found to have combined protein C and protein S deficiency.
I
Intervention
Enoxaparin 60 mg subcutaneously every 12 hours for one week, overlapped with warfarin 5 mg everyday, continued indefinitely

Recurrent or unusual presentations of DVT warrant investigation for hereditary thrombophilia, which may necessitate lifelong anticoagulation.

Limitations

  • Factor V Leiden and mutant prothrombin (Prothrombin 20210A) assay could not be done because these tests are not available in Bangladesh.

Cite This Study

Rahman et al. (2012) conducted a case report in Recurrent Deep Vein Thrombosis (DVT) and Thrombophilia (n=1). Anticoagulant therapy (heparin followed by warfarin) was evaluated. A 40-year-old man with recurrent deep vein thrombosis was diagnosed with hereditary thrombophilia due to combined protein C and protein S deficiency, requiring lifelong warfarin prophylaxis.

synapsesocial.com/papers/6a92dddb6724a03bc54f54b2https://doi.org/10.4070/kcj.2012.42.5.345
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Trends in the Incidence of Deep Vein Thrombosis and Pulmonary Embolism1998 · 2,680 citations
  2. 2Deficiencies of Coagulation-Inhibiting and Fibrinolytic Proteins in Outpatients with Deep-Vein Thrombosis1990 · 449 citations
  3. 3Hereditary Thrombophilia and Venous Thromboembolism1998 · 73 citations
  4. 4Homocysteine and Thrombotic Disease1997 · 426 citations
  5. 5Co-inheritance of the 20210A Allele of the Prothrombin Gene Increases the Risk of Thrombosis in Subjects with Familial Thrombophilia1997 · 176 citations