Key result
MH-NAFLD was associated with a higher prevalence of elevated carotid intima-media thickness compared to healthy controls (26% vs 2%, p=0.001), with MRI-PDFF being a superior predictor than ultrasound.
Why the study?
While subclinical atherosclerosis in MASLD is established, its presence in patients with metabolically healthy non-alcoholic fatty liver disease (MH-NAFLD) remains unclear.
Does MRI-PDFF improve the prediction of subclinical atherosclerosis compared to ultrasonography in patients with metabolically healthy non-alcoholic fatty liver disease?
Observational (n=100)
No
Does MRI-PDFF improve the prediction of subclinical atherosclerosis compared to ultrasonography in patients with metabolically healthy non-alcoholic fatty liver disease?
Absolute Event Rate: 26% vs 2%
p-value: p=0.001
MRI-PDFF is superior to conventional ultrasonography in predicting subclinical atherosclerosis (elevated CIMT) in patients with metabolically healthy non-alcoholic fatty liver disease.
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May enhance CIMT prediction in metabolically healthy NAFLD; leaves open whether it improves risk stratification without prospective validation.
Bhawariya et al. (2025) conducted an observational in Metabolically healthy non-alcoholic fatty liver disease (MH-NAFLD) (n=100). Hepatic steatosis (MH-NAFLD) vs. Age- and sex-matched healthy controls was evaluated on Elevated carotid intima-media thickness (CIMT ≥ 0.84 mm) (p=0.001). MH-NAFLD was associated with a higher prevalence of elevated carotid intima-media thickness compared to healthy controls (26% vs 2%, p=0.001), with MRI-PDFF being a superior predictor than ultrasound.
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