Key result
Higher body mass index was independently associated with an increased risk of preoperative oxygenation impairment in patients with acute aortic syndrome (OR 1.34).
Why the study?
The study aimed to determine the relationship between body mass index and the risk of acute aortic syndrome with preoperative oxygenation impairment.
Does excessive BMI increase the risk of preoperative oxygenation impairment in patients with acute aortic syndrome?
Observational (n=230)
No
Does excessive BMI increase the risk of preoperative oxygenation impairment in patients with acute aortic syndrome?
Odds Ratio: 1.34 (95% CI 1.15–1.56)
p-value: p=<0.001
Excessive BMI is an independent risk factor for preoperative oxygenation impairment in patients with acute aortic syndrome, with a particularly high risk observed in obese patients with elevated diastolic blood pressure.
May identify higher-risk acute aortic syndrome patients for oxygenation screening; extends meta-analytic associations but requires prospective confirmation.
Objective The study aimed to determine the relationship between body mass index (BMI) and the risk of acute aortic syndrome (AAS) with preoperative oxygenation impairment. Methods A meta-analysis of published observational studies involving BMI and AAS with preoperative oxygenation impairment was conducted. A total of 230 patients with AAS were enrolled for retrospective analysis. All patients were divided into 2 groups (Non-oxygenation impairment group and Oxygenation impairment group). Logistic regression analysis was performed to assess the relation between BMI and the risk of preoperative oxygenation impairment after the onset of AAS. Dose-response relationship curve and subgroup analysis were conducted to test the reliability of BMI as an independent factor of it. Results For the meta-analysis, the quantitative synthesis indicated that excessive BMI increased the risk of preoperative oxygenation impairment (OR: 1.30, 95% CI: 1.05-1.60, Pheterogeneity = 0.001). For the retrospective analysis, a significant association was observed after adjusting for a series of variables. BMI was significantly related to preoperative oxygenation impairment after the onset of AAS (OR: 1.34, 95% CI: 1.15-1.56, p <0.001), and compared with normal weight group (18.5 kg/m2 ≤ BMI < 23.0 kg/m2), the individuals with excessive BMI were at higher risk of preoperative oxygenation impairment for the obese group (BMI ≥ 25 kg/m2) (OR: 17.32, 95% CI: 4.03-74.48, p <0.001). A J-shape curve in dose-response relationship analysis further confirmed their positive correlation. Subgroup analysis showed that diastolic blood pressure (DBP) ≥ 90mmHg carried an excess risk of preoperative oxygenation impairment in obese patients. Conclusion Excessive BMI was an independent risk factor for AAS with preoperative oxygenation impairment.
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Zhang et al. (2022) conducted an observational in Acute aortic syndrome (n=230). Body mass index vs. Normal weight was evaluated on Preoperative oxygenation impairment (PaO2/FiO2 ratio ≤ 200 on admission) (OR 1.34, 95% CI 1.15-1.56, p=<0.001). Higher body mass index was independently associated with an increased risk of preoperative oxygenation impairment in patients with acute aortic syndrome (OR 1.34).
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