Key result
Low BMI is linked to ~145% higher 1-year mortality after transfemoral TAVR.
Why the study?
Conflicting results have been reported regarding the impact of body mass index on outcomes of patients undergoing transcatheter aortic valve replacement.
Does low BMI predict higher 1-year mortality in patients with severe aortic stenosis undergoing transfemoral TAVR?
Population
491 severe aortic stenosis patients undergoing transfemoral TAVR between May 2007 and December 2014
Comparison
Low BMI (<20) vs normal (20-24.9), overweight (25-30), and obese (>30) BMI groups
Design
Cohort study
Follow-up
1 year
Authors
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May flag frailty in TAVR candidates; hypothesis-generating and should not yet change practice.
Cohort (n=491)
Does low BMI predict higher 1-year mortality in patients with severe aortic stenosis undergoing transfemoral TAVR?
Hazard Ratio: 2.45
p-value: p=0.01
In patients undergoing transfemoral TAVR for severe aortic stenosis, a BMI <20 kg/m2 is an independent predictor of 1-year mortality and should be considered a frailty marker.
Koifman et al. (2015) conducted a cohort in Severe aortic stenosis (n=491). Low body mass index (<20 kg/m2) vs. Normal and above-normal body mass index was evaluated on All-cause mortality at 1 year (HR 2.45, p=0.01). Low body mass index (<20 kg/m2) was an independent predictor of 1-year all-cause mortality in patients undergoing transfemoral TAVR for severe aortic stenosis (HR 2.45, p=0.01).
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