Key result
Genomic analysis of respiratory samples from Peru identified two novel human enterovirus C genotypes that belong to a distinct clade and exhibit significant genomic rearrangement.
The discovery of two novel human enterovirus C genotypes in Peru suggests that several novel HEV-C serotypes are currently circulating worldwide.
Suggests wider global HEV-C circulation; leaves open questions on prevalence, pathogenicity, and surveillance needs.
We report the discovery of two enteroviruses detected in nasopharyngeal samples obtained from subjects with respiratory disease in Peru. Phylogenetic analysis indicated that both viruses belong to a clade within the species Human enterovirus C, which includes the recently characterized human enteroviruses 109 and 104. Members of this clade have undergone significant genomic rearrangement, as indicated by deletions in the hypervariable region of the 5' UTR and the VP1 protein, as well as recombination within the non-structural genes. Our findings and review of published sequences suggests that several novel human enterovirus C serotypes are currently circulating worldwide.
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Tokarz et al. (2012) studied Respiratory disease (n=244). Genomic analysis of novel human enterovirus C genotypes was evaluated on Genomic sequence and phylogenetic relationship. Genomic analysis of respiratory samples from Peru identified two novel human enterovirus C genotypes that belong to a distinct clade and exhibit significant genomic rearrangement.
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