Key result
Sequence alignment and phylogenetic analysis revealed that the HEV-C105 isolate from a pediatric patient exhibits a 5'-UTR distinct from all previously known enteroviruses.
Case Report (n=1)
No
The identification of a novel HEV-C105 strain with a divergent 5'-UTR highlights the need for updated diagnostic assays to prevent missed detections of emerging enteroviruses.
Human enterovirus (HEV) 105 was first reported in 2012 in children from Peru and Congo. We report on the identification of a novel HEV-C105 strain in a pediatric patient in Cyprus with an upper respiratory tract infection. Sequence alignment and phylogenetic analysis of 5'-UTRs of all known HEVs revealed that our isolate belongs to a group of recently identified HEV-C viruses exhibiting a 5'-UTR distinct from all other previously known enteroviruses. This has important implications for diagnosis, as this region is the primary target for diagnostic assays. Increased awareness in laboratories may thus increase the rate of detection of enteroviruses belonging to this subspecies, or lead to the discovery of further genotypes.
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Richter et al. (2013) conducted a case report in Upper respiratory tract infection (HEV-C105 infection) (n=1). Sequence alignment and phylogenetic analysis of 5'-UTRs was evaluated on Identification and characterization of HEV-C105 strain 5'-UTR. Sequence alignment and phylogenetic analysis revealed that the HEV-C105 isolate from a pediatric patient exhibits a 5'-UTR distinct from all previously known enteroviruses.
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