Key result
Pediatric subjects with enterovirus meningitis had significantly higher rates of disseminated infection than adults, with 62.5% vs 0% testing positive in both stool and blood.
Why the study?
Does the pattern of enterovirus viral shedding differ between pediatric and adult subjects with acute EV meningitis?
Observational
No
Does the pattern of enterovirus viral shedding differ between pediatric and adult subjects with acute EV meningitis?
Absolute Event Rate: 62.5% vs 0%
Enterovirus-disseminated infections are predominant in pediatric subjects compared to adults, showing different patterns of viral shedding that may inform patient care.
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May support age-stratified EV testing in meningitis; leaves open whether dissemination patterns should guide care.
Cordey et al. (2017) conducted an observational in Acute enterovirus meningitis. Pediatric age group vs. Adult age group was evaluated on Enterovirus positivity in stool and blood. Pediatric subjects with enterovirus meningitis had significantly higher rates of disseminated infection than adults, with 62.5% vs 0% testing positive in both stool and blood.
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