Key result
A cloned DNA probe complementary to the measles virus nucleocapsid protein mRNA successfully detected specific measles virus sequences in brain autopsy material from a patient with SSPE.
Population
CV-1 line of African green monkey kidney cells infected with measles virus, and brain autopsy material from…
Design
Preclinical
Authors
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May support measles persistence in SSPE; leaves open causal mechanisms and clinical relevance.
The cloned measles virus DNA can be used as a probe to study the structure and expression of the measles genome, particularly in central nervous system diseases like SSPE.
Gorecki et al. (1980) studied Subacute sclerosing panencephalitis (SSPE) / Measles virus infection. Cloned measles virus DNA probe was evaluated on Detection of measles virus sequences. A cloned DNA probe complementary to the measles virus nucleocapsid protein mRNA successfully detected specific measles virus sequences in brain autopsy material from a patient with SSPE.
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