Key result
In situ hybridization reveals measles viral RNA in nuclear structures, suggesting active transcription and replication.
Population
Vero cells infected with measles virus
Design
Preclinical
Follow-up
up to 36 hours
Authors
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May inform nuclear-targeted antivirals for measles; leaves open relevance to human cells and pathogenesis.
The cellular distribution of measles virus RNA molecules varies during infection, suggesting the nucleus plays a more active role in viral transcription and replication than previously expected.
Fournier et al. (1984) studied Measles virus infection (in vitro). Measles virus infection was evaluated on Localization of viral RNA. In situ hybridization of measles virus-infected Vero cells revealed viral RNA in the cytoplasm, nuclear structures, and chromosomes, suggesting an active nuclear role in viral transcription and replication.
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