Hypertensive myocardial fibrosis
Key result
Agents directly blocking the renin-angiotensin system (ACE-inhibitors and ARBs) appear particularly effective in reducing hypertensive myocardial fibrosis compared to beta-blockers and diuretics.
Why the study?
Do renin-angiotensin system blockers reduce myocardial fibrosis better than other antihypertensive agents in patients with hypertensive LVH?
Population
Patients with arterial hypertension and left ventricular hypertrophy (LVH)
Comparison
Antihypertensive agents directly blocking the… vs Other antihypertensive agents such as…
Design
Review
Authors
Discussion
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Member takes
Implication
May favor RAS blockers for fibrosis regression in hypertensive LVH; leaves open prospective RCT confirmation.
Structured PICO
Do renin-angiotensin system blockers reduce myocardial fibrosis better than other antihypertensive agents in patients with hypertensive LVH?
P
Population
Patients with arterial hypertension and left ventricular hypertrophy (LVH)
I
Intervention
Antihypertensive agents directly blocking the renin-angiotensin system (ACE-inhibitors and ARBs)
C
Comparator
Other antihypertensive agents such as beta-blockers and diuretics
O
Outcome
Regression of myocardial fibrosis and reduction in left ventricular masssurrogate
Renin-angiotensin system blockers (ACEi/ARBs) may be more effective than other antihypertensives at regressing myocardial fibrosis in hypertensive LVH, improving both cardiac mass and tissue quality.
Limitations
- It remains to be investigated whether fibrosis and its regression correlate equally, or even better, than mass and its regression with subsequent cardiovascular events.
Cite This Study
Cuspidi et al. (2005) conducted a review in Hypertensive myocardial fibrosis. Antihypertensive therapy (ACE-inhibitors and ARBs) vs. Beta-blockers and diuretics was evaluated. Agents directly blocking the renin-angiotensin system (ACE-inhibitors and ARBs) appear particularly effective in reducing hypertensive myocardial fibrosis compared to beta-blockers and diuretics.