What question did this study set out to answer?

To assess quantitative and qualitative changes in the sensitivity of early insulin secretion following glucose stimulation across different stages of carbohydrate tolerance.

January 1, 1981Diabetes Care

Quantitative and qualitative changes in the early insulin response to glucose in subjects with impaired carbohydrate tolerance

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Authors

KRKlaus P. RatzmannInstitute for Diabetes Gerhardt Katsch BSBernd SchulzUnited States Department of Veterans Affairs PHP HeinkeInstitute for Diabetes Gerhardt Katsch

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Implication

Controlled physiological study demonstrates blunted early insulin secretion in carbohydrate-intolerant individuals, indicating diminished pancreatic beta-cell sensitivity.

Key Points

To assess quantitative and qualitative changes in the sensitivity of early insulin secretion following glucose stimulation across different stages of carbohydrate tolerance.
Assessed 73 nonobese individuals suspected of impaired carbohydrate tolerance and 24 matched healthy controls without a family history of diabetes.
Characterized carbohydrate tolerance status (normal, borderline, or pathologic) using a 2-hour primed glucose infusion test (12 mg/kg-min with a 0.33 g/kg priming dose).
Administered staircase pulse glucose stimulations of 1.0, 2.5, and 5.0 g at 30-minute intervals to evaluate early insulin responses (ΔIRI area, 0–5 min) and dose-response dynamics.
Early insulin response (ΔIRI area, 0–5 min) during the glucose infusion test was significantly reduced in individuals with normal, borderline, and pathologic carbohydrate tolerance relative to controls.
Controls displayed a significant, dose-dependent rise in maximum insulin response (Δmax IRI) during staircase stimulation, whereas this relationship was lost and peak responses were significantly diminished across all suspected tolerance groups.
The glucose-insulin dose-response curve shifted to the right in all carbohydrate-intolerant groups compared to healthy controls, demonstrating reduced beta-cell sensitivity.

Cite This Study

Ratzmann et al. (1981) studied this question.

synapsesocial.com/papers/6a92ea5ff7c7f77f695c1910 https://doi.org/10.2337/diacare.4.1.85

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Implication

Controlled physiological study demonstrates blunted early insulin secretion in carbohydrate-intolerant individuals, indicating diminished pancreatic beta-cell sensitivity.

Quantitative and qualitative changes in the early insulin response to glucose in subjects with impaired carbohydrate tolerance

Discussion

Member takes

Implication

Key Points

Cite This Study

Quantitative and qualitative changes in the early insulin response to glucose in subjects with impaired carbohydrate tolerance

Discussion

Member takes

Implication

Key Points

Cite This Study

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