Key result
Computational modeling indicates that arterial-to-venous oxygen shunting increases as lumen separation decreases and vein wrapping increases, favoring larger vessels.
Population
Preglomerular vascular geometry in the renal cortex
Design
Preclinical
Authors
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Geometric factors may enhance renal AV shunting in larger vessels; hypothesis-generating for cortical hypoxia mechanisms, pending in vivo validation.
Computational modeling suggests that arterial-to-venous oxygen shunting in the renal cortex is favored in larger vessels common to the cortical and medullary circulations due to geometric factors like lumen separation and vein wrapping.
Gardiner et al. (2012) studied Renal oxygen transport. Computational modeling of preglomerular vascular geometry was evaluated on Arterial-to-venous (AV) oxygen shunting. Computational modeling indicates that arterial-to-venous oxygen shunting increases as lumen separation decreases and vein wrapping increases, favoring larger vessels.
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