Key result
Heating rheumatoid serum to 56° C for 30 minutes reduced its precipitating ability and caused a concurrent loss of hemagglutinating activity.
Heating rheumatoid serum to 56° C for 30 minutes reduces its precipitating ability and hemagglutinating activity.
Should not change clinical serologic testing; leaves open heat-sensitive factors in rheumatoid factor activity.
To determine the heat lability of rheumatoid factor, rheumatoid serum was heated to 56° C. for 30 minutes. This amount of heat reduced precipitating ability and caused a concurrent loss of hemagglutinating activity in the supernatant, as measured by the F II hemagglutination system.
No takes yet. Share an insight, caveat, or question.
Epstein et al. (1961) studied this question. Heating rheumatoid serum to 56° C for 30 minutes reduced its precipitating ability and caused a concurrent loss of hemagglutinating activity.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: