Key result
A review of previous studies indicates that microemboli and global cerebral hypoperfusion are major aetiologies of central nervous system impairment following cardiac surgery.
Why the study?
What are the aetiologies, manifestations, and interventions for cerebral dysfunction after cardiopulmonary bypass?
What are the aetiologies, manifestations, and interventions for cerebral dysfunction after cardiopulmonary bypass?
This review outlines the major causes (microemboli and global cerebral hypoperfusion), manifestations, and intraoperative interventions for central nervous system dysfunction following cardiac surgery.
Informs perioperative neuroprotection strategies in cardiac surgery; leaves open validation of specific interventions in prospective trials.
Central nervous system dysfunction following cardiac surgery remains a significant cause of morbidity and mortality, with the reported incidence of dysfunction varying widely between studies. Microemboli and global cerebral hypoperfusion are implicated as the major aetiologies of CNS impairment. Preoperative and intraoperative variables influencing the patient's risk of complications remain controversial. Based on a review of previous studies, this paper outlines the major causes and manifestations of CNS impairment as well as the intraoperative interventions currently advocated to improve the cerebral outcome of cardiac patients.
No takes yet. Share an insight, caveat, or question.
Campbell et al. (1990) conducted a review in Central nervous system dysfunction following cardiac surgery. Intraoperative interventions was evaluated. A review of previous studies indicates that microemboli and global cerebral hypoperfusion are major aetiologies of central nervous system impairment following cardiac surgery.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: