Electrostatic, Linearity and Sensitivity Analysis of Neutral Biomolecules Using NC-JL-GAA MOSFET-Based Biosensor

This study focuses on the intricate design and comprehensive investigation of electrostatic properties, analog analysis, and linearity characteristics associated with various neutral biomolecules. These investigations were conducted under varying dielectric constants, utilizing a novel device designated as the Negative Capacitance Junctionless Gate-All-Around (NC-JL-GAA) MOSFET. To evaluate the device’s sensing behavior, the analysis incorporated several neutral biomolecules, including Deoxyribonucleic Acid (DNA), Amino-propyl-tri-ethoxysilane (APTES), Streptavidin, Biotin, and air. The sensitivity of the electrostatic characteristics was thoroughly examined to ascertain the extent of their responsiveness. The simulated results demonstrate that the Subthreshold Swing (SS), Drain-Induced Barrier Lowering (DIBL), and OFF-state current (IOFF) consistently exhibit optimal performance across all investigated conditions. Notably, DNA yielded the highest ON-current (ION) and ION/IOFF ratio, thereby highlighting its superior interaction with the channel potential. These simulations were performed using the ATLAS™ 3D device simulator (SILVACO), which was calibrated against a device previously reported by other research groups. For validation purposes, the electrical and sensing characteristics of the device were benchmarked against those of other reported FET-based biosensors.