Key result
Streptozotocin-induced diabetes had a more pronounced influence on drug-induced relaxation in isolated resistance vessels than hypertension, without indicating generalised endothelial damage.
Population
Isolated mesenteric small arteries from spontaneously hypertensive rats treated with streptozotocin to…
Comparison
Vasodilator drugs vs Vessels from control rats
Design
Preclinical
Authors
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Diabetes may impair resistance-vessel reactivity more than hypertension in this model; leaves open translation to human comorbid disease.
In a rat model of co-existing hypertension and diabetes, the diabetic state has a more pronounced effect on vascular reactivity than hypertension, though neither causes generalized endothelial damage in resistance arteries.
Kam et al. (1994) studied Hypertension and diabetes mellitus. Streptozotocin (STZ) vs. Control WKY and control SHR was evaluated on Drug-induced endothelium-independent and -dependent relaxation in isolated mesenteric small arteries. Streptozotocin-induced diabetes had a more pronounced influence on drug-induced relaxation in isolated resistance vessels than hypertension, without indicating generalised endothelial damage.
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