Key result
A massive 2000 mg oral warfarin overdose exhibited rapid plasma clearance with a half-life of 21.7 hours and no convincing evidence of dose-dependent disposition.
A massive overdose of warfarin (2000 mg) demonstrated a rapid decline in plasma levels with a half-life of 21.7 hours and no evidence of dose-dependent disposition.
Should not change overdose protocols; leaves open whether rapid clearance generalizes beyond this case.
The plasma pharmacokinetics of warfarin were studied in a patient who took an overdose of warfarin (2000 mg by mouth), together with 25 X 10(4) units of heparin administered subcutaneously. The plasma warfarin level fell rapidly (half-life, 21.7 h), and there was no convincing evidence for dose-dependency in its disposition.
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Hackett et al. (1985) studied this question. A massive 2000 mg oral warfarin overdose exhibited rapid plasma clearance with a half-life of 21.7 hours and no convincing evidence of dose-dependent disposition.
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