Key result
Doxorubicin exposure in rats time-dependently depressed hepatic CYP2C11 metabolic capacity and significantly reduced the intrinsic clearance of unbound tolbutamide.
Why the study?
The study was conducted to examine the effect of doxorubicin on hepatic CYP2C expression and tolbutamide metabolism in rats, and whether tolbutamide pharmacokinetics were altered by doxorubicin exposure.
Population
Rats
Comparison
Doxorubicin exposure vs control
Design
Animal pharmacokinetic and laboratory study
Follow-up
Up to day 4
Authors
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May indicate CYP-mediated interactions warranting vigilance; hypothesis-generating for human translation.
Fukuno et al. (2019) studied this question. Doxorubicin vs. Control group was evaluated on Hepatic expression of CYP2C and its activity for metabolizing tolbutamide. Doxorubicin exposure in rats time-dependently depressed hepatic CYP2C11 metabolic capacity and significantly reduced the intrinsic clearance of unbound tolbutamide.
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