Key result
Highest versus lowest systolic blood pressure quartile at peak exercise (≥180 vs. ≤145 mmHg) was associated with an increased risk of MACE (HR 1.30; 95% CI 1.05-1.61).
Why the study?
The physiologic response to exercise may provide valuable prognostic information, but the association of BP measurements during exercise stress testing with long-term risk of MACE and new-onset hypertension required investigation.
Does elevated systolic blood pressure during treadmill exercise testing predict future cardiovascular events and new-onset hypertension in patients without prior cardiovascular disease?
Population
14 792 patients aged 35-75 years without a history of cardiovascular disease undergoing treadmill EST
Comparison
Highest vs lowest SBP quartiles at rest, submaximal exercise, peak exercise, and recovery
Design
Retrospective cohort study
Follow-up
Median 6.5 years
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Peak-exercise SBP may aid risk stratification; leaves open whether targeting it reduces MACE or incident hypertension.
Cohort (n=14,792)
Does elevated systolic blood pressure during treadmill exercise testing predict future cardiovascular events and new-onset hypertension in patients without prior cardiovascular disease?
Hazard Ratio: 1.3 (95% CI 1.05–1.61)
Elevated systolic blood pressure during rest, exercise, and recovery phases of exercise stress testing independently predicts long-term risk of MACE and new-onset hypertension.
A 2021 study conducted a cohort in No history of cardiovascular disease (n=14,792). High systolic blood pressure during exercise stress testing vs. Low systolic blood pressure was evaluated on Major adverse cardiovascular event (myocardial infarction, stroke or death) (HR 1.30, 95% CI 1.05-1.61). Highest versus lowest systolic blood pressure quartile at peak exercise (≥180 vs. ≤145 mmHg) was associated with an increased risk of MACE (HR 1.30; 95% CI 1.05-1.61).
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