Key result
High cardiorespiratory fitness was associated with lower AIx75 vs low fitness (-10% vs 2%, p=0.019), while moderate fitness enhanced post-exercise FMD recovery (8.5% vs 6.7%, p=0.028).
Why the study?
Poor cardiorespiratory fitness may mediate vascular impairments at rest and after acute exercise in young healthy individuals.
Does an acute bout of aerobic exercise affect flow mediated dilation and vascular augmentation index differently based on baseline cardiorespiratory fitness in young healthy adults?
Cross-Sectional (n=43)
Does an acute bout of aerobic exercise affect flow mediated dilation and vascular augmentation index differently based on baseline cardiorespiratory fitness in young healthy adults?
Standardized Mean Difference: 1.07
Absolute Event Rate: -10% vs 2%
p-value: p=0.019
Resting vascular indices are not significantly influenced by cardiorespiratory fitness independent of body fat, but FMD recovery responses to exercise may be enhanced in individuals with moderate fitness levels.
May enhance post-exercise FMD recovery in moderate-fitness youth; leaves open CRF effects on AIx independent of body fat.
Poor cardiorespiratory fitness may mediate vascular impairments at rest and following an acute bout of exercise in young healthy individuals. This study aimed to compare flow mediated dilation (FMD) and vascular augmentation index (AIx75) between young adults with low, moderate, and high levels of cardiorespiratory fitness before and after an acute bout of aerobic exercise. Forty-three participants (22 men; 21 women) between 18 and 29 years of age completed the study. Participants were classified into low, moderate, and high health-related cardiorespiratory fitness groups according to age- and sex-based relative maximal oxygen consumption (V˙ O2 max) percentile rankings. FMD was performed using Doppler ultrasound and AIx75 was performed using pulse wave analysis at baseline and 60-min after a 30-min bout of treadmill running at 70 % V˙ O2 max. A significant interaction (p = 0.047; ηp2 = 0.142) was observed, with the moderate fitness group exhibiting a higher FMD post-exercise compared with baseline (6.7 % ± 3.1 % vs. 8.5 % ± 2.8 %, p = 0.028; d = 0.598). We found a significant main effect of group for AIx75 (p = 0.023; ηp2 = 0.168), with the high fitness group exhibiting lower AIx75 compared to low fitness group (−10 % ± 10 % vs. 2 % ± 10 %, respectively, p = 0.019; g = 1.07). This was eliminated after covarying for body fat percentage (p = 0.489). Our findings suggest that resting FMD and AIx75 responses are not significantly influenced by cardiorespiratory fitness, but FMD recovery responses to exercise may be enhanced in individuals with moderate cardiorespiratory fitness levels.
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Landers‐Ramos et al. (2023) conducted a cross-sectional in Healthy (n=43). Cardiorespiratory fitness level vs. Low cardiorespiratory fitness was evaluated on Vascular augmentation index (AIx75) (g = 1.07, p=0.019). High cardiorespiratory fitness was associated with lower AIx75 vs low fitness (-10% vs 2%, p=0.019), while moderate fitness enhanced post-exercise FMD recovery (8.5% vs 6.7%, p=0.028).
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