Key result
Pre-treating mice with Aloe vera gel extract (1 mg/kg/d) for 1 week significantly suppressed ethanol-induced liver triglyceride elevation and lipogenic gene expression.
Why the study?
Does Aloe vera gel extract prevent ethanol-induced hepatic lipid accumulation in mice?
Does Aloe vera gel extract prevent ethanol-induced hepatic lipid accumulation in mice?
Aloe vera gel extract attenuates ethanol-induced hepatic lipid accumulation in mice by suppressing the expression of lipogenic genes.
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Findings in mice should not alter clinical management of alcohol-related liver disease; hypothesis-generating for future human studies.
Saito et al. (2012) studied Ethanol-induced transient fatty liver. Aloe vera gel extract (AVGE) vs. Control group was evaluated on Liver triglyceride (TG) level and expression of lipogenic genes. Pre-treating mice with Aloe vera gel extract (1 mg/kg/d) for 1 week significantly suppressed ethanol-induced liver triglyceride elevation and lipogenic gene expression.
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