Key result
Partial inhibition of fatty acid oxidation with trimetazidine reduces lactate production during ischaemia, resulting in clinical benefit in patients with angina pectoris.
Design
Review
Authors
Loading...
Supports metabolic modulation in angina; leaves open confirmation by prospective RCTs before practice change.
Partial inhibition of fatty acid oxidation in ischemic myocardium reduces lactate production and H+ accumulation, offering a metabolic approach to treating angina pectoris.
William C. Stanley (2001) conducted a review in Myocardial ischaemia and angina pectoris. Trimetazidine was evaluated. Partial inhibition of fatty acid oxidation with trimetazidine reduces lactate production during ischaemia, resulting in clinical benefit in patients with angina pectoris.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: