Key result
Metabolic therapies that inhibit myocardial fatty acid oxidation, such as ranolazine and trimetazidine, are as effective as traditional hemodynamic therapies at reducing the frequency of angina.
Metabolic therapies offer an effective alternative or add-on treatment for angina by optimizing myocardial energy metabolism without altering hemodynamics.
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Metabolic agents may be considered for angina; leaves open confirmation of outcome benefits in prospective RCTs.
William C. Stanley (2004) conducted a review in Angina and myocardial ischemia. Metabolic therapies (oxfenicine, ranolazine, trimetazidine) vs. Traditional hemodynamic therapies was evaluated. Metabolic therapies that inhibit myocardial fatty acid oxidation, such as ranolazine and trimetazidine, are as effective as traditional hemodynamic therapies at reducing the frequency of angina.
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