Key result
Plasma digoxin concentrations correlated poorly with signs or symptoms commonly used to assess digoxin effect in general practice patients.
Why the study?
Does plasma digoxin concentration correlate with clinical signs and symptoms in patients receiving digoxin in general practice?
Cohort
Does plasma digoxin concentration correlate with clinical signs and symptoms in patients receiving digoxin in general practice?
Plasma digoxin concentrations correlate poorly with clinical signs and symptoms in general practice, highlighting the potential value of objective laboratory monitoring.
Clinical signs may inadequately guide digoxin therapy in primary care; leaves open whether routine concentration monitoring improves outcomes.
1 As part of a prospective study on the use of digoxin in a general practice, plasma digoxin concentrations were measured in all patients receiving the drug. 2 A low mean plasma digoxin concentration was observed, suggesting a cautious approach to digitalization. 3 The correlation between plasma digoxin concentration and signs or symptoms commonly used in the assessment of digoxin effect was poor. 4 It was concluded that the measurement of plasma digoxin could be of assistance in a variety of clinical settings within a general practice.
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Dw et al. (1977) conducted a cohort in Patients receiving digoxin. Plasma digoxin concentration was evaluated on Correlation between plasma digoxin concentration and signs or symptoms of digoxin effect. Plasma digoxin concentrations correlated poorly with signs or symptoms commonly used to assess digoxin effect in general practice patients.
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