Key result
Outpatient digoxin levels show high variability and link to lower arterial BP in men.
Why the study?
What factors correlate with plasma digoxin concentration in outpatients on digoxin therapy?
Observational (n=73)
What factors correlate with plasma digoxin concentration in outpatients on digoxin therapy?
Plasma digoxin concentrations show high variability and may be negatively correlated with blood pressure in men, suggesting BP might be a determinant for glycoside therapy dosing.
Variability in digoxin levels supports therapeutic monitoring; cross-sectional data leave open blood pressure as a potential dosing factor in men.
Forty‐eight male and 25 female consecutive outpatients on digoxin therapy have been studied in respect of their glycoside level in plasma by the 86Rb method. The variability of plasma concentrations was high at all dose levels. For men those on the lowest dose had the lowest plasma digoxin concentration. Men had a negative correlation between plasma concentration of digoxin and arterial BP and GOT. For women there was a higher variability of concentration than in men and their mean values at different dose levels did not differ. No correlation with interval from last dose and sampling or with serum creatinine values was detected. The study indicates that the BP level might be a determinant for glycoside therapy. Patients with high BP may tolerate higher doses.
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Schröder et al. (1973) conducted an observational in Outpatients on digoxin therapy (n=73). Digoxin therapy was evaluated on Plasma concentration of digoxin. Plasma concentration of digoxin in outpatients showed high variability at all dose levels, with a negative correlation observed between plasma concentration and arterial blood pressure in men.
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