Key result
Serum digoxin concentrations showed no significant day-to-day variation between day 7 (1.52 nmol/l) and day 8 (1.48 nmol/l) in medical patients continuing home therapy.
Observational (n=70)
Serum digoxin concentrations show minimal day-to-day variation in hospitalized patients on a stable home dose, and this variation is not correlated with clinical factors such as age, sex, weight, or renal function.
Suggests stable digoxin levels may allow consistent monitoring intervals in hospital; leaves open effects on outcomes or dosing in wider populations.
Serum digoxin concentration was measured in 70 medical patients 7 and 8 days after admission to hospital. The digoxin treatment taken at home was continued in hospital. There was no statistically significant difference between mean digoxin concentrations in samples taken at day 7 (1.52 nmol/l) and day 8 (1.48 nmol/l). The variation in serum digoxin concentration from day to day expressed as SD was 0.25 nmol/l; 95% confidence limits were +/- 0.51 nmol/l, and 99% confidence limits +/- 0.67 nmol/l. Variations in serum digoxin concentration were not correlated to age, sex, body weight, serum creatinine and the oral dose of digoxin.
No takes yet. Share an insight, caveat, or question.
Serup et al. (1983) conducted an observational in Medical patients on digoxin (n=70). Digoxin vs. Day 8 vs Day 7 was evaluated on Serum digoxin concentration. Serum digoxin concentrations showed no significant day-to-day variation between day 7 (1.52 nmol/l) and day 8 (1.48 nmol/l) in medical patients continuing home therapy.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: