Key result
Elevated myocardial digoxin linked to ~75% incidence of serious ventricular arrhythmias after cardiac surgery.
Why the study?
What is the relationship between serum and myocardial digoxin concentrations in patients undergoing cardiac surgery?
Observational (n=27)
What is the relationship between serum and myocardial digoxin concentrations in patients undergoing cardiac surgery?
Absolute Event Rate: 75% vs 8.7%
Myocardial digoxin concentrations are approximately 70 times higher than serum concentrations, and elevated myocardial levels (>100 ng/g) may be associated with an increased risk of post-operative ventricular arrhythmias.
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High myocardial digoxin may raise post-operative arrhythmia risk; small cohort leaves open need for prospective tissue-level studies.
Carroll et al. (1973) conducted an observational in Cardiac surgery (n=27). Myocardial digoxin concentration >100 ng/g vs. Myocardial digoxin concentration <100 ng/g was evaluated on Serious post-operative ventricular arrhythmias. Myocardial digoxin concentrations >100 ng/g were associated with serious post-operative ventricular arrhythmias (75% vs 8.7% for <100 ng/g) in patients undergoing cardiac surgery.
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