Key result
In 13 cadavers, heart tissue digoxin concentrations showed a linear correlation with whole blood concentrations, with the best correlation found in the ventricular muscle (r = 0.86).
Population
13 cadavers who before death had been on maintenance digoxin therapy
Design
Case_series
Authors
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May inform postmortem digoxin interpretation; hypothesis-generating and requires prospective validation before any clinical use.
Observational (n=13)
Effect estimate: r = 0.86
This autopsy study demonstrates a linear correlation between whole blood and heart tissue concentrations of digoxin, with the highest concentrations found in the septal muscle.
Karjalainen et al. (1974) conducted an observational in Deceased patients previously on maintenance digoxin therapy (n=13). Maintenance digoxin therapy was evaluated on Correlation between heart tissue and whole blood digoxin concentrations (r = 0.86). In 13 cadavers, heart tissue digoxin concentrations showed a linear correlation with whole blood concentrations, with the best correlation found in the ventricular muscle (r = 0.86).
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