Key result
Post-mortem analysis revealed that myocardial binding of digoxin is significantly higher in infants than in adults, whereas concentrations in other tissues did not differ significantly.
Why the study?
Does the post-mortem tissue distribution and concentration of digoxin differ between infants and adults on maintenance therapy?
Population
12 infants and 17 adults who received digoxin maintenance therapy prior to death
Comparison
Digoxin maintenance therapy vs Adults on digoxin maintenance therapy
Design
Cross-sectional
Authors
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May warrant cautious infant digoxin dosing; hypothesis-generating for age-specific pharmacokinetics.
Observational (n=29)
Yes
Does the post-mortem tissue distribution and concentration of digoxin differ between infants and adults on maintenance therapy?
Post-mortem analysis reveals that myocardial binding of digoxin is higher in infants than in adults, despite similar concentrations in other tissues.
Andersson et al. (1975) conducted an observational in Patients on digoxin maintenance therapy (n=29). Digoxin maintenance therapy vs. Adults was evaluated on Post-mortem tissue concentrations of digoxin. Post-mortem analysis revealed that myocardial binding of digoxin is significantly higher in infants than in adults, whereas concentrations in other tissues did not differ significantly.
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