Key result
Antemortem creatinine clearance correlates with postmortem myocardium-to-serum digoxin concentration ratios.
Why the study?
The variability in tissue to serum ratios of digoxin and its relation to renal function was not well understood.
Does antemortem creatinine clearance correlate with the myocardium:serum concentration ratio of digoxin?
Population
15 patients evaluated at autopsy
Comparison
Myocardium versus serum digoxin concentrations related to creatinine clearance
Design
Observational study measuring digoxin concentrations at autopsy
Authors
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May explain reduced digoxin distribution volume in renal impairment; leaves open dosing implications pending prospective data.
Observational (n=15)
Does antemortem creatinine clearance correlate with the myocardium:serum concentration ratio of digoxin?
The myocardium:serum concentration ratio of digoxin correlates with creatinine clearance, which helps explain the smaller apparent volume of distribution of digoxin in patients with impaired renal function.
Jusko et al. (1974) reported an observational. Renal function (creatinine clearance) was evaluated on Correlation between myocardium:serum concentration ratio of digoxin and creatinine clearance. Antemortem creatinine clearance was significantly correlated with the myocardium:serum concentration ratio of digoxin measured at autopsy.
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