Key result
Digoxin maintenance therapy yields highly consistent heart-to-serum concentration ratios in cardiac surgery patients.
Why the study?
Does serum digoxin concentration correlate with heart tissue concentration in patients on maintenance digoxin therapy?
Population
Patients undergoing surgery for coronary artery or valvular disease who were on maintenance doses of digoxin.
Design
Cross-sectional
Authors
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Supports serum digoxin monitoring as surrogate for myocardial levels in maintenance therapy; leaves open prospective validation of dosing precision.
Does serum digoxin concentration correlate with heart tissue concentration in patients on maintenance digoxin therapy?
Serum digoxin concentrations correlate closely with myocardial tissue concentrations in patients on maintenance therapy.
Güllner et al. (1974) studied this question. Digoxin maintenance therapy resulted in remarkably similar heart-to-serum concentration ratios with small variance in patients undergoing cardiac surgery.
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