Key result
Stopping digoxin 48 hours before cardiopulmonary bypass yielded plasma concentrations <1.0 nmol/l, whereas 3 patients who developed postoperative pulsus bigeminus received 0.5 mg 24 hours prior.
Why the study?
Does discontinuing digoxin 48 hours prior to surgery prevent postoperative cardiotoxicity in patients undergoing cardiopulmonary bypass?
Observational (n=32)
Does discontinuing digoxin 48 hours prior to surgery prevent postoperative cardiotoxicity in patients undergoing cardiopulmonary bypass?
Cardiopulmonary bypass does not significantly alter plasma or tissue digoxin concentrations, but discontinuing digoxin 48 hours before surgery may help avoid postoperative cardiotoxicity.
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Discontinuing digoxin 48h pre-CPB may reduce postoperative arrhythmias; hypothesis-generating and requires randomized confirmation.
Carruthers et al. (1975) conducted an observational in Patients undergoing cardiopulmonary bypass on long-term digoxin treatment (n=32). Digoxin vs. Different discontinuation intervals (e.g., 48 hours vs 24 hours) was evaluated on Plasma, myocardial, and skeletal muscle digoxin concentrations before and at the end of bypass. Stopping digoxin 48 hours before cardiopulmonary bypass yielded plasma concentrations <1.0 nmol/l, whereas 3 patients who developed postoperative pulsus bigeminus received 0.5 mg 24 hours prior.
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