Key result
In patients on long-term therapy, myocardial digoxin concentration varied widely (mean 77.7 ng/g) and showed no simple relationship with plasma levels.
Population
8 patients on maintenance treatment with digoxin undergoing mitral valve replacement
Design
Cross-sectional
Authors
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Plasma digoxin levels may not predict myocardial concentrations; leaves open whether tissue monitoring improves dosing in long-term therapy.
Observational (n=8)
Plasma digoxin levels do not reliably predict myocardial tissue concentrations in patients on maintenance therapy.
Coltart et al. (1972) conducted an observational in Mitral valve disease requiring replacement (n=8). Digoxin was evaluated on Digoxin content in left ventricular papillary muscle, skeletal muscle, and plasma. In patients on long-term therapy, myocardial digoxin concentration varied widely (mean 77.7 ng/g) and showed no simple relationship with plasma levels.
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