Key result
In children undergoing open heart surgery, the specific assay method yielded a mean specific-to-nonspecific digoxin concentration ratio of 0.74 for serum and 0.81 for atrial tissue.
Why the study?
How do specific and nonspecific assay methods compare in determining myocardial and serum digoxin concentrations in children?
Population
25 children undergoing open heart surgery
Comparison
Specific assay method for measuring digoxin… vs Nonspecific, direct radioimmunoassay method
Design
Cross-sectional
Authors
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Caution advised with nonspecific digoxin assays in children; leaves open need for specific methods in monitoring.
Cross-Sectional (n=25)
How do specific and nonspecific assay methods compare in determining myocardial and serum digoxin concentrations in children?
Specific assay methods using HPLC before radioimmunoassay yield lower measured digoxin concentrations in serum and atrial tissue compared to nonspecific methods in children.
Wagner et al. (1983) conducted a cross-sectional in Children undergoing open heart surgery (n=25). Specific (S) assay method (HPLC before radioimmunoassay) vs. Nonspecific (NS) direct radioimmunoassay method was evaluated on Serum and right atrial digoxin concentrations and S/NS ratio. In children undergoing open heart surgery, the specific assay method yielded a mean specific-to-nonspecific digoxin concentration ratio of 0.74 for serum and 0.81 for atrial tissue.
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