Key result
Myocardial digoxin levels were considerably higher in infants (211.8 ng/g) compared to adults (35.1 ng/g) undergoing open heart surgery, despite similar serum levels.
Why the study?
Is there a difference in myocardial and serum digoxin concentrations between infants and adults undergoing open heart surgery?
Observational (n=29)
Is there a difference in myocardial and serum digoxin concentrations between infants and adults undergoing open heart surgery?
Absolute Event Rate: 211.8% vs 35.1%
Infants have significantly higher myocardial uptake of digoxin compared to adults despite similar serum levels, indicating age-related pharmacokinetic differences.
No takes yet. Share an insight, caveat, or question.
May warrant age-specific digoxin dosing caution in infants; leaves open need for prospective outcome studies before practice change.
Myung K. Park (1982) conducted an observational in Open heart surgery (n=29). Digoxin vs. Adults was evaluated on Right atrial appendage (RAA) digoxin levels (ng/g wet weight). Myocardial digoxin levels were considerably higher in infants (211.8 ng/g) compared to adults (35.1 ng/g) undergoing open heart surgery, despite similar serum levels.
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