Key result
Oral digoxin shortens preejection periods in neonates and infants, with larger doses producing no further changes.
Why the study?
Does oral digoxin improve systolic time intervals in neonates and infants with and without congestive heart failure?
Does oral digoxin improve systolic time intervals in neonates and infants with and without congestive heart failure?
Small doses of digoxin (30 µg/kg) achieve maximal inotropic effect in neonates and infants, challenging the need for larger digitalizing loading doses.
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Supports reduced digoxin loading doses in neonates and infants; hypothesis-generating pending randomized outcome data.
Lévy et al. (1972) studied Congestive heart failure and normal physiology (n=37). Digoxin vs. Baseline (before administration) was evaluated on Systolic time intervals (Preejection period and ejection time). Administration of oral digoxin (30 µg/kg) significantly shortened the preejection period in neonates and infants, with larger doses (80 µg/kg) producing no further changes.
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