Key result
Initial weight-based digoxin regimens safely guide clinical titration and avoid toxicity in infants.
Why the study?
What is the optimal and safe digitalizing and maintenance dosage of digoxin in infants?
Population
Normal infants and infants with heart disease
Design
Review
Authors
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May support titratable digoxin dosing in infants with monitoring; leaves open need for prospective validation before routine use.
What is the optimal and safe digitalizing and maintenance dosage of digoxin in infants?
Proposes a standardized but titratable digoxin dosing regimen for infants to achieve clinical efficacy while avoiding toxicity.
Sapin et al. (1956) studied heart disease. Digoxin was evaluated. A digoxin regimen of 75 µg/kg initially over 24 hours followed by 25 µg/kg daily maintenance is recommended for infants, with further titration based on clinical response.
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