Why the study?
How is digoxin distributed in the tissues and erythrocytes of infants compared to adults?
Population
19 infants
Comparison
Digoxin therapy (digitalization and maintenance) vs Adults (historical/previous data)
Design
Cross-sectional
Authors
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Infants have a greater apparent volume of distribution and higher myocardial uptake of digoxin compared to adults, which may explain their need for larger therapeutic doses.
How is digoxin distributed in the tissues and erythrocytes of infants compared to adults?
Infants have a greater apparent volume of distribution and higher myocardial uptake of digoxin compared to adults, which may explain their need for larger therapeutic doses.
Gorodischer et al. (1976) studied this question.
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