Recipient hearts from cardiac transplantation provide a unique tissue source to study the intramyocardial distribution of digoxin.
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Enables direct human myocardial digoxin sampling; leaves open generalizability to other drugs or clinical decision-making.
Data defining the intramyocardial distribution of digoxin and its relationship to serum levels are lacking primarily owing to the limitation of an adequate supply of myocardial tissue for study. By using the recipient heart removed at the time of cardiac transplantation a supply of myocardial tissue is realized for more definitive studies of the distribution of digoxin, as reported in this study.
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Coltart et al. (1975) studied this question.
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