Why the study?
How do serum concentrations of digitoxin and digoxin vary day-to-day in patients on maintenance therapy?
Population
145 cases with various heart diseases receiving maintenance doses of digitalis
Design
Cohort
Authors
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Digitoxin may yield steadier serum levels than digoxin on maintenance therapy; leaves open outcome impact and needs prospective validation.
How do serum concentrations of digitoxin and digoxin vary day-to-day in patients on maintenance therapy?
Digitoxin exhibits less day-to-day serum concentration variability than digoxin, and its levels are dependent on serum albumin concentrations.
Takahashi et al. (1979) studied this question.
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