Key result
Higher serum digoxin concentration is linked to digitalis toxicity with ~88% predictive accuracy.
Why the study?
Does serum digoxin concentration measurement accurately predict digitoxicity in patients with suspected digitalis-induced arrhythmias?
Observational (n=100)
Does serum digoxin concentration measurement accurately predict digitoxicity in patients with suspected digitalis-induced arrhythmias?
Absolute Event Rate: 2.88% vs 1%
p-value: p=<0.0001
Serum digoxin concentration is a useful but imperfect diagnostic test for digitoxicity, limited by a high false-negative rate.
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May aid suspected digitoxicity diagnosis but limited by false-negatives; leaves open prospective validation in arrhythmia cohorts.
Bernabei et al. (1980) conducted an observational in Suspected digitalis-induced arrhythmias (n=100). Serum digoxin concentration vs. Nontoxic group was evaluated on Mean serum digoxin concentration (p=<0.0001). Serum digoxin concentration was significantly higher in patients with digitalis toxicity (2.88 vs 1.00 ng/ml, p<0.0001), yielding 88% predictive accuracy, 89% specificity, and 62% sensitivity.
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