Key result
In a healthy Japanese population, Lipoprotein (a) levels were highly skewed, significantly higher in females, and showed no significant correlation with conventional cardiovascular risk factors.
Cross-Sectional (n=497)
No
In a healthy rural Japanese population, Lp(a) levels are highly skewed, higher in females, and do not correlate with conventional cardiovascular risk factors.
To reveal a distribution of lipoprotein (a) (Lp(a)) in Japan and to explore relationships between Lp(a) and conventional cardiovascular risk factors, transaminase (GOT(AST), GPT(ALT)) and γ- gulutamyltranspeptidase (y-GTP), a cross-sectional study in a healthy population was performed. We measured serum Lp(a) of 497 apparently healthy subjects aged 40-69 years old in a rural area in Japan ; 198 males and 299 females. Lp(a) frequency distributions were highly skewed to the low level. Serum Lp(a) level is significantly higher in the females (15.1+/-1.08 mg/dl) than in the males (12.0+/-1.01 mg/dl). Among males the median and mean log Lp(a) levels increased according to age. Pearson's correlation analysis showed statistically significant correlations (p<0.05) between Lp(a) and GOT, GPT, γ-GTP, total cholesterol (TCH), triglyceride, but no statistically significant correlations between Lp(a) and body mass index, blood pressure, high-density lipoprotein cholesterol, blood sugar, corrected TCH for males. On the other hand, the same analysis showed no statistically significant correlation among Lp(a) and each item observed for females. We suppose Lp(a) is not related to conventional cardiovascular risk factors. J Epidemiol, 1994; 4 : 163-169.
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Hiraokal et al. (1994) conducted a cross-sectional in Healthy (n=497). Lipoprotein (a) level was evaluated on Correlation between Lipoprotein (a) and conventional cardiovascular risk factors. In a healthy Japanese population, Lipoprotein (a) levels were highly skewed, significantly higher in females, and showed no significant correlation with conventional cardiovascular risk factors.
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