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The synthesis of racemic diethyl succinate and dimethyl adipate substituted in their 2 and 3 position respectively by usual heterocyclic bases are described via the Michael addition of nucleobases on diethyl maleate and dimethyl (E)-3-hexene-1, 6-dioate. The Michael adducts are further reduced to afford the corresponding carboacyclonucleosides.
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Perbost et al. (1992) studied this question.
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