Biological dosimetry with the Comet and Micronucleus tests in patients with serious hyperthyroidism, toxic adenoma and Plummer disease treated with I131

F. Gómez; Deidamia Franco; Virginia Fernández Peralta; Francisco Cabañas Duarte; Mark A. Jara Ruiz; Jessica M. Jara Ruiz; Elías D. Jara Ruiz; Miguel Leonardo Arias-Duarte; Jorge Antonio Jara Yorg

doi:10.18004/rcfacen.2021.12.2.88

December 30, 2021Reportes científicos de la FACENOpen Access

Biological dosimetry with the Comet and Micronucleus tests in patients with serious hyperthyroidism, toxic adenoma and Plummer disease treated with I131

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Key Points

Determine the absorbed radiation doses of iodine-131 in hyperthyroidism treatments using MIRD physical dosimetry and evaluate the feasibility of biological dosimetry via comet and micronucleus assays.
Calculated physical absorbed doses using the Medical Internal Radiation Dose (MIRD) formalism based on conjugate imaging protocols in nuclear medicine.
Assessed cellular radiation sensitivity and biological damage using comet and micronucleus tests in patients treated with iodine-131 for hyperthyroid conditions.
The percentage of DNA in the comet tail reliably reflected the absorption capacity of iodine-131 in the thyroid gland.
Reductions in blood iodine-131 concentration coincided with increased DNA damage repair over an internal therapeutic distribution window of 50 to 100 days.

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Implication

Demonstrates that comet assay DNA damage tracks iodine-131 absorption and clearance in hyperthyroidism, indicating its utility as a biological dosimeter.

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Gómez et al. (2021) studied this question.

synapsesocial.com/papers/6a93057504488afd95f0b0a7 https://doi.org/10.18004/rcfacen.2021.12.2.88

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Biological dosimetry with the Comet and Micronucleus tests in patients with serious hyperthyroidism, toxic adenoma and Plummer disease treated with I131

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Abstract

Discussion

Cite This Study

Biological dosimetry with the Comet and Micronucleus tests in patients with serious hyperthyroidism, toxic adenoma and Plummer disease treated with I131

Key Points

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Abstract

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Cite This Study

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