Key result
Nitrous oxide 40% administered with oxygen or oxygen/nitrogen significantly prolonged the pre-ejection period by 25% and 22%, respectively, indicating depressed cardiac performance.
Why the study?
Does inhalation of nitrous oxide affect systolic time intervals and cardiac performance in healthy persons?
Does inhalation of nitrous oxide affect systolic time intervals and cardiac performance in healthy persons?
Nitrous oxide at 40% concentration depresses cardiac performance by significantly prolonging the pre-ejection period in healthy individuals.
Answers are grounded in this paper and cite their sources.
Nitrous oxide may impair cardiac performance in healthy individuals; leaves open effects in patients or on outcomes.
The effects of inhalation of oxygen, nitrous oxide/oxygen and nitrous oxide/nitrogen/oxygen on systolic time intervals (PEP (pre-ejection period) and LVET (left ventricular ejection time) were investigated in eight healthy persons. Nitrous oxide 40%, administered with oxygen or oxygen/nitrogen, prolonged PEP significantly by 25% and 22%, respectively. Inhalation of oxygen also prolonged PEP but to a significantly minor degree. LVET, heart rate and MAP were unchanged during the experiments. Derivatives from the systolic time intervals, i.e. PEP/LVET, I/PEP2 and ejection fraction changed significantly in the nitrous oxide groups. It is concluded that nitrous oxide depresses cardiac performance, to some degree, even when administered at a rather low concentration.
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Eriksen et al. (1980) studied Healthy (n=8). Nitrous oxide vs. Oxygen was evaluated on Pre-ejection period (PEP). Nitrous oxide 40% administered with oxygen or oxygen/nitrogen significantly prolonged the pre-ejection period by 25% and 22%, respectively, indicating depressed cardiac performance.
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