Key result
A human TAR RNA-binding protein (TRBP) was isolated and found to activate the HIV-1 LTR synergistically with Tat function.
Population
HeLa complementary DNA
Design
Preclinical
Authors
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No immediate clinical implications for HIV care; leaves open TRBP as a potential host target for future studies.
Identification of a human TAR RNA-binding protein (TRBP) that synergizes with Tat to activate HIV-1 gene expression.
Gatignol et al. (1991) studied HIV-1. TAR RNA-binding protein (TRBP) was evaluated on HIV-1 LTR activation. A human TAR RNA-binding protein (TRBP) was isolated and found to activate the HIV-1 LTR synergistically with Tat function.
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