Key result
Higher body mass index in adults with congenital heart disease was associated with lower mortality, particularly in symptomatic patients (HR 0.94; 95% CI 0.90-0.98; p=0.002).
Why the study?
Does higher body mass index (BMI) improve survival in adults with congenital heart disease?
Population
3,069 adults with congenital heart disease, median age 32.6 years, under follow-up at a single institution…
Comparison
Body mass index categories vs Comparison across different BMI categories
Design
Cohort
Authors
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Should not yet change weight management in congenital heart disease; leaves open mechanisms and causality of the obesity paradox.
Cohort (n=3,069)
No
Does higher body mass index (BMI) improve survival in adults with congenital heart disease?
Hazard Ratio: 0.94 (95% CI 0.9–0.98)
p-value: p=0.002
In adults with congenital heart disease, higher BMI is associated with lower mortality, particularly in symptomatic patients with complex defects, suggesting an 'obesity paradox' potentially driven by cardiac cachexia.
Brida et al. (2017) conducted a cohort in Adult congenital heart disease (ACHD) (n=3,069). Higher body mass index (BMI) vs. Lower BMI was evaluated on All-cause and cardiac mortality (HR 0.94, 95% CI 0.90 to 0.98, p=0.002). Higher body mass index in adults with congenital heart disease was associated with lower mortality, particularly in symptomatic patients (HR 0.94; 95% CI 0.90-0.98; p=0.002).
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