April 3, 2019Physical TherapyOpen Access

Effect of Blood Flow Restriction Training on Quadriceps Muscle Strength, Morphology, Physiology, and Knee Biomechanics Before and After Anterior Cruciate Ligament Reconstruction: Protocol for a Randomized Clinical Trial

Q: What is the clinical evidence from this study?

Study design: RCT. Population: Anterior Cruciate Ligament (ACL) tear (n=60). Intervention: Blood flow restriction training (BFRT) vs. Physical therapy plus placebo BFRT (standard of care). Primary outcome: Quadriceps strength (peak quadriceps torque, rate of torque development).

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Key result

Blood flow restriction training will be evaluated for its efficacy in restoring quadriceps strength and knee biomechanics compared to standard of care in a planned randomized clinical trial of 60 patients with anterior cruciate ligament reconstruction.

Why the study?

Quadriceps strength deficits often persist for years after anterior cruciate ligament reconstruction, and the effect and physiological mechanisms of blood flow restriction training remain to be evaluated.

Does active blood flow restriction training added to physical therapy improve quadriceps strength in patients with an ACL tear?

Comparison

Physical therapy plus active BFRT vs physical therapy plus placebo BFRT

Design

Randomized, double-blind, placebo-controlled clinical trial

Authors

LELauren N. EricksonUniversity of Kentucky KLKathryn LucasCreighton University KDKylie DavisUniversity of Kentucky

Discussion

Member takes

Implication

Does not yet support BFR in post-ACL rehab; this RCT will test effects on quadriceps strength and biomechanics.

Study Design

Type

RCT (n=60)

Blinding

Double-blind

Randomization

Permuted blocks of 4 for each sex

Multicenter

Yes

Structured PICO

Does active blood flow restriction training added to physical therapy improve quadriceps strength in patients with an ACL tear?

Population

60 participants aged 15 to 40 years with an anterior cruciate ligament tear planned for reconstruction, followed for up to 7 months.

Intervention

Physical therapy plus active blood flow restriction training (BFRT) (presurgical 3 times per week for 4 weeks, and postsurgical 3 times per week for 4 to 5 months)

Comparator

Physical therapy plus placebo BFRT (standard of care group)

Outcome

Quadriceps strength (peak quadriceps torque, rate of torque development)surrogate

This protocol outlines a randomized trial to evaluate whether blood flow restriction training improves quadriceps strength and knee biomechanics after ACL reconstruction.

Limitations

Physical therapists administering the intervention cannot be blinded to the treatment groups.
Potential inability to conduct an intent-to-treat analysis or missing data imputation if sample sizes are not large enough due to dropouts.
The study assesses only one set of BFRT treatment parameters, meaning more effective criteria might exist.
Therapists will not be blinded

Cite This Study

Erickson et al. (2019) conducted an RCT in Anterior Cruciate Ligament (ACL) tear (n=60). Blood flow restriction training (BFRT) vs. Physical therapy plus placebo BFRT (standard of care) was evaluated on Quadriceps strength (peak quadriceps torque, rate of torque development). Blood flow restriction training will be evaluated for its efficacy in restoring quadriceps strength and knee biomechanics compared to standard of care in a planned randomized clinical trial of 60 patients with anterior cruciate ligament reconstruction.

synapsesocial.com/papers/6a930a6a05c76830a0c6b550 https://doi.org/10.1093/ptj/pzz062

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Effect of Blood Flow Restriction Training on Quadriceps Muscle Strength, Morphology, Physiology, and Knee Biomechanics Before and After Anterior Cruciate Ligament Reconstruction: Protocol for a Randomized Clinical Trial

Discussion

Member takes

Implication

Study Design

Structured PICO

Limitations

Cite This Study

Effect of Blood Flow Restriction Training on Quadriceps Muscle Strength, Morphology, Physiology, and Knee Biomechanics Before and After Anterior Cruciate Ligament Reconstruction: Protocol for a Randomized Clinical Trial

Discussion

Member takes

Implication

Study Design

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider