What is the clinical evidence from this study?

Study design: Other. Intervention: 3,3',5-triiodo-L-thyronine (T3). Primary outcome: Liver angiotensinogen mRNA and Plasma angiotensinogen concentration (PAC).

January 1, 1990The Japanese Journal of PharmacologyOpen Access

Effects of thyroid hormone on angiotensinogen and renin messenger RNA levels in rats.

View Full Paper

Ask AI

Bookmark

Key result

Treatment with T3 at doses of 0.1 and 1 mg/kg increased liver angiotensinogen mRNA by 2 to 3 times at 8 to 12 hours, followed by an increase in plasma angiotensinogen concentration.

Authors

SKShoji KimuraJikei University School of Medicine HIHiroshi IwaoCross-Cutting Cardiology KFKiyoshi FukuiKansai University

Discussion

Member takes

Implication

T3-angiotensinogen link remains preclinical; leaves open relevance to thyroid-related hypertension or HF in humans.

PICO

Population

Rats treated with T3 to study angiotensinogen and renin gene expression.

Intervention / Comparator

3,3',5-triiodo-L-thyronine (T3) (0.1 and 1 mg/kg of body weight)

Primary Outcome

Liver angiotensinogen mRNA and Plasma angiotensinogen concentration (PAC)

Cite This Study

Kimura et al. (1990) studied this question. 3,3',5-triiodo-L-thyronine (T3) was evaluated on Liver angiotensinogen mRNA and Plasma angiotensinogen concentration (PAC). Treatment with T3 at doses of 0.1 and 1 mg/kg increased liver angiotensinogen mRNA by 2 to 3 times at 8 to 12 hours, followed by an increase in plasma angiotensinogen concentration.

synapsesocial.com/papers/6a930aa6a1aae70ebbc6b2fe https://doi.org/10.1254/jjp.52.281

View Full Paper

Ask AI

Bookmark

January 1, 1990The Japanese Journal of PharmacologyOpen Access

Effects of thyroid hormone on angiotensinogen and renin messenger RNA levels in rats.

View Full Paper

Ask AI

Bookmark

Key result

Treatment with T3 at doses of 0.1 and 1 mg/kg increased liver angiotensinogen mRNA by 2 to 3 times at 8 to 12 hours, followed by an increase in plasma angiotensinogen concentration.

Authors

SKShoji KimuraJikei University School of Medicine HIHiroshi IwaoCross-Cutting Cardiology KFKiyoshi FukuiKansai University

Discussion

Member takes

Implication

T3-angiotensinogen link remains preclinical; leaves open relevance to thyroid-related hypertension or HF in humans.

PICO

Population

Rats treated with T3 to study angiotensinogen and renin gene expression.

Intervention / Comparator

3,3',5-triiodo-L-thyronine (T3) (0.1 and 1 mg/kg of body weight)

Primary Outcome

Liver angiotensinogen mRNA and Plasma angiotensinogen concentration (PAC)

Cite This Study

synapsesocial.com/papers/6a930aa6a1aae70ebbc6b2fe https://doi.org/10.1254/jjp.52.281

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

View Full Paper

Ask AI

Bookmark